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Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway.
Yao Y, Li X, Cheng L, Wu X, Wu B. Yao Y, et al. Bioengineered. 2021 Dec;12(1):4032-4043. doi: 10.1080/21655979.2021.1951929. Bioengineered. 2021. PMID: 34288822 Free PMC article.
Increasing evidence has confirmed the vital roles of circular RNAs (CircRNAs) in the drug resistance of breast cancer (BC). Herein, we intended to study the effect of circular RNA FAT atypical cadherin 1 (circFAT1) on BC oxaliplatin (OX) resistance and find out the …
Increasing evidence has confirmed the vital roles of circular RNAs (CircRNAs) in the drug resistance of breast cancer (BC). He …
SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis.
Li J, Xuan JW, Khatamianfar V, Valiyeva F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ. Li J, et al. J Pathol. 2014 Oct;234(2):178-89. doi: 10.1002/path.4374. Epub 2014 Aug 4. J Pathol. 2014. PMID: 24827423
Here, we report that Ska1 over-expression promotes prostate tumourigenesis. Immunohistochemistry and quantitative RT-PCR analysis revealed that Ska1 was over-expressed in human prostatic intra-epithelial neoplasia (PIN), the most likely prostate cancer precur …
Here, we report that Ska1 over-expression promotes prostate tumourigenesis. Immunohistochemistry and quantitative RT-PCR analysis rev …
SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma.
Pu Y, Han J, Zhang M, Liu M, Abdusamat G, Liu H. Pu Y, et al. Aging (Albany NY). 2022 Dec 2;14(23):9679-9698. doi: 10.18632/aging.204418. Epub 2022 Dec 2. Aging (Albany NY). 2022. PMID: 36462498 Free PMC article.
Functionally, SKA1 knockdown on ccRCC cells reduced cancer cell motility both in vivo and in vitro research. ...Our findings may provide a new way of researching SKA1-regulated tumor metastasis, and indicate that SKA1 is a prospective therapeutic targe …
Functionally, SKA1 knockdown on ccRCC cells reduced cancer cell motility both in vivo and in vitro research. ...Our findings m …
LINC00339 promotes growth and invasiveness of hepatocellular carcinoma by the miR-1182/SKA1 pathway.
Xiao J, Yu H, Ma Z. Xiao J, et al. Onco Targets Ther. 2019 Jun 6;12:4481-4488. doi: 10.2147/OTT.S207397. eCollection 2019. Onco Targets Ther. 2019. PMID: 31239716 Free PMC article.
The lncRNA LINC00339 was reported to regulate the development of lung cancer or breast cancer. However, whether LINC00339 participates in HCC progression remains unclear. ...Mechanistically, LINC00339 could interact with miR-1182 to promote SKA1 expres …
The lncRNA LINC00339 was reported to regulate the development of lung cancer or breast cancer. However, whether LINC003 …
Identification of Hub Genes Using Co-Expression Network Analysis in Breast Cancer as a Tool to Predict Different Stages.
Fu Y, Zhou QZ, Zhang XL, Wang ZZ, Wang P. Fu Y, et al. Med Sci Monit. 2019 Nov 23;25:8873-8890. doi: 10.12659/MSM.919046. Med Sci Monit. 2019. PMID: 31758680 Free PMC article.
BACKGROUND Breast cancer has a high mortality rate and is the most common cancer of women worldwide. ...All 49 hub genes have been shown to be upregulated, and 19 of the 49 hub genes are significantly upregulated in breast cancer tissue. The rol …
BACKGROUND Breast cancer has a high mortality rate and is the most common cancer of women worldwide. ...All 49 hub gene …
Immunological role and prognostic value of the SKA family in pan-cancer analysis.
Li Z, Huang L, Li J, Yang W, Li W, Long Q, Dai X, Wang H, Du G. Li Z, et al. Front Immunol. 2023 Apr 26;14:1012999. doi: 10.3389/fimmu.2023.1012999. eCollection 2023. Front Immunol. 2023. PMID: 37180139 Free PMC article.
In addition, the potential value of the SKA score was identified to predict immunotherapy response for melanoma and bladder cancer. We also demonstrated a correlation between SKA1/2/3 and the response to drug treatment across cancers and the promising potential of t …
In addition, the potential value of the SKA score was identified to predict immunotherapy response for melanoma and bladder cancer. W …
Integrative analysis of prognostic value and immune infiltration of spindle and kinetochore-associated family members in breast cancer.
Ding J, He X, Wang J, Cao G, Chen S, Yuan L, Chen B, Xiong M. Ding J, et al. Bioengineered. 2021 Dec;12(2):10905-10923. doi: 10.1080/21655979.2021.1995576. Bioengineered. 2021. PMID: 34845974 Free PMC article.
ONCOMINE, UALCAN, GEPIA, Kaplan-Meier Plotter, cBioPortal and TIMER databases were performed to analyze the expression, prognosis, mutation, immune infiltration and potential biological mechanisms of SKA1/2/3 in BC. Our results showed that SKA1/2/3 expression was up …
ONCOMINE, UALCAN, GEPIA, Kaplan-Meier Plotter, cBioPortal and TIMER databases were performed to analyze the expression, prognosis, mutation, …
SKA2/FAM33A: A novel gene implicated in cell cycle, tumorigenesis, and psychiatric disorders.
Xie M, Bu Y. Xie M, et al. Genes Dis. 2018 Nov 12;6(1):25-30. doi: 10.1016/j.gendis.2018.11.001. eCollection 2019 Mar. Genes Dis. 2018. PMID: 30906829 Free PMC article. Review.
It has been demonstrated that SKA2, along with its coworkers SKA1 and SKA3, constitutes the SKA complex which plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing during mitosis. SKA2 is over-expressed both in cancer ce …
It has been demonstrated that SKA2, along with its coworkers SKA1 and SKA3, constitutes the SKA complex which plays a critical role i …
Risk stratification of triple-negative breast cancer with core gene signatures associated with chemoresponse and prognosis.
Kim EK, Park AK, Ko E, Park WY, Lee KM, Noh DY, Han W. Kim EK, et al. Breast Cancer Res Treat. 2019 Nov;178(1):185-197. doi: 10.1007/s10549-019-05366-x. Epub 2019 Jul 24. Breast Cancer Res Treat. 2019. PMID: 31342312
PURPOSE: Neoadjuvant chemotherapy studies have consistently reported a strong correlation between pathologic response and long-term outcome in triple-negative breast cancer (TNBC). We aimed to define minimal gene signatures for predicting chemoresponse by a three-st …
PURPOSE: Neoadjuvant chemotherapy studies have consistently reported a strong correlation between pathologic response and long-term outcome …
Regulation of spindle and kinetochore-associated protein 1 by antitumor miR-10a-5p in renal cell carcinoma.
Arai T, Okato A, Kojima S, Idichi T, Koshizuka K, Kurozumi A, Kato M, Yamazaki K, Ishida Y, Naya Y, Ichikawa T, Seki N. Arai T, et al. Cancer Sci. 2017 Oct;108(10):2088-2101. doi: 10.1111/cas.13331. Epub 2017 Aug 19. Cancer Sci. 2017. PMID: 28746769 Free PMC article.
Knockdown of SKA1 inhibited cancer cell migration and invasion in RCC cells. Overexpression of SKA1 was observed in RCC tissues and TKI-treated RCC tissues. Moreover, analysis of The Cancer Genome Atlas database demonstrated that low expression of miR- …
Knockdown of SKA1 inhibited cancer cell migration and invasion in RCC cells. Overexpression of SKA1 was observed in RCC …
11 results